Dates, times and teams may change without notice.
| Week | Day | Date | Teams | Time |
|---|---|---|---|---|
| Preseason | Sunday | August 28 | Detroit @ Pittsburgh | 4:30 p.m. |
| Week 1 | Sunday | September 11 | Pittsburgh @ Cincinnati | 1 p.m. |
| Week 1 | Sunday | September 11 | Kansas City @ Arizona | 4:25 p.m. |
| Week 2 | Sunday | September 18 | New England @ Pittsburgh | 1 p.m. |
| Week 2 | Sunday | September 18 | Cincinnati @ Dallas | 4:25 p.m. |
| Week 3 | Sunday | September 25 | Houston @ Chicago | 1 p.m. |
| Week 4 | Sunday | October 2 | Buffalo @ Baltimore | 1 p.m. |
| Week 4 | Sunday | October 2 | New England @ Green Bay | 4:25 p.m. |
| Week 5 | Sunday | October 9 | Pittsburgh @ Buffalo | 1 p.m. |
| Week 6 | Sunday | October 16 | Baltimore @ NY Giants | 1 p.m. |
| Week 6 | Sunday | October 16 | Buffalo @ Kansas City | 4:25 p.m. |
| Week 7 | Sunday | October 23 | Detroit @ Dallas | 1 p.m. |
| Week 8 | Sunday | October 30 | Miami @ Detroit | 1 p.m. |
| Week 9 | Sunday | November 6 | Miami @ Chicago | 1 p.m. |
| Week 9 | Sunday | November 6 | LA Rams @ Tampa Bay | 4:25 p.m. |
| Week 10 | Sunday | November 13 | Denver @ Tennessee | 1 p.m. |
| Week 11 | Sunday | November 20 | Cleveland @ Buffalo | 1 p.m. |
| Week 11 | Sunday | November 20 | Dallas @ Minnesota | 4:25 p.m. |
| Week 12 | Thursday | Thanksgiving | Buffalo @ Detroit | 12:30 p.m. |
| Week 12 | Sunday | November 27 | Cincinnati @ Tennessee | 1 p.m. |
| Week 13 | Sunday | December 4 | NY Jets @ Minnesota | 1 p.m. |
| Week 13 | Sunday | December 4 | Kansas City @ Cincinnati | 4:25 p.m. |
| Week 14 | Sunday | December 11 | Cleveland @ Cincinnati | 1 p.m. |
| Week 15 | Sunday | December 18 | Kansas City @ Houston | 1 p.m. |
| Week 15 | Sunday | December 18 | Cincinnati @ Tampa Bay | 4:25 p.m. |
| Week 16 | Saturday | December 24 | Buffalo @ Chicago | 1 p.m. |
| Week 16 | Sunday | December 25 | Denver @ LA Rams | 4:30 p.m. |
| Week 17 | Sunday | January 1 | Pittsburgh @ Baltimore | 1 p.m. |
| Week 17 | Sunday | January 1 | Minnesota @ Green Bay | 4:25 p.m. |
| Week 18 | Sunday | January 8 | TBD | 1 p.m. |
| Week 18 | Sunday | January 8 | TBD | 4:25 p.m. |
| Playoffs | January 14 or 15 | AFC Wildcard Playoff | ||
| Playoffs | January 21 or 22 | AFC Divisional Playoff | ||
| Playoffs | January 29 | AFC Championship |